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Vice Provost for Research and Economic Development
205 Administration Building
1 University of Arkansas
Fayetteville, AR 72701

Office: (479) 575-5901
Fax: (479) 575-3846
research@uark.edu



Live, Vertebrate Animals as Research Subjects (IACUC)

The University of Arkansas endorses and supports the responsible use of animals in research and teaching. Its Vertebrate Animals policy is designed to ensure that animals are used in a humane, productive, and responsible fashion. Faculty, staff, and students must comply with all applicable provisions of the Animal Welfare Act and other Federal statutes and regulations relating to the use of live vertebrate animals in research and teaching.


Institutional Animal Care & Use Committee (IACUC)

The IACUC is charged with monitoring adherence the University's Policy on Animal Care and Use and federal and state statutes and regulations. All research or teaching using live vertebrate animals must have prior, written approval of an Vertebrate Animals Protocol. Vertebrate Animals Protocols are not required for agricultural teaching applications involving the non-stressful observation of farm animals, demonstration of judging techniques, demonstration of accepted farm management practices, or normal use of farm animals in production.


IACUC Fall 2013-14 Meeting Schedule

The IACUC meets on the first Friday of each month. Investigators are not expected to attend the meeting unless specifically requested to do so. Since the IACUC cannot approve protocols without a quorum of the voting members present, meetings are occasionally rescheduled. Contact the IACUC Program Manager to confirm the meeting date for protocol submission.


Deadlines

Protocols must be received at least seven (7) working days prior to the meeting.


Protocol Submission

Investigators should submit both a signed hard copy and an electronic copy to the IACUC Program Manager.


Membership


Training

Laboratory Animal Training Association Online Training Program
This is a secure website. Please contact Tony Munn for a username and password which will allow you to log in.


New protocols will not be reviewed by the IACUC until the Principal Investigator and all individuals engaged in the research, care and/or handling of animals complete two base modules. The required modules are The Humane Use of Laboratory Animals Module and the Policies and Procedures Module. These modules must be accessed via web interface and will take about 30 minutes each to complete. Investigators, staff and student are not charged for this training. All costs are paid by the Office of Research Support and Sponsored Programs and the Dale Bumpers College of Agricultural, Food, and Life Sciences.


You will receive immediate notification that you have completed the module(s). You are advised to print and save all notifications. The IACUC Program Manager will be informed automatically of all completions so you do not need to notify the IACUC of completion.


Several optional modules are available, e.g. animal care and handling, surgical procedures and other techniques specific to animal species used in research. You are encouraged to complete as many modules as you wish even though completion of just the two basic modules is mandatory at this time.


Newcastle University Procedures with Care Website

  • Administration of Substances: A series of tutorials to assist research workers develop their skills in the administration of substances to laboratory rodents. Videos include, for example, handling and restraint, oral gavage, IP, IM, and SC injection.
  • Aseptic Technique in Rodent Surgery: A comprehensive guide to help research workers apply best practice in aseptic surgical techniques in laboratory rodents.


Reporting Concerns About the Care and Use of Live, Vertebrate Animals

Any individual who has specific concerns that animals are not being used in a humane and responsible manner by University faculty, staff, or students is encouraged to report such concerns to any member of the IACUC Program Staff. The IACUC Chair, or other members of the IACUC appointed by the Chair, will investigate. If deficiencies are found, the IACUC will take whatever steps are necessary to ensure compliance with the federal and state regulations and the University's policy on the care and use of research animals.


Regulatory Agencies

Responsibilities for ensuring compliance with Animal Welfare regulations are shared between three primary federal entities, USDA, DHHS, and FDA. Their responsibilities, as agreed upon in a renewed Memorandum of Understanding (2011) (http://grants.nih.gov/grants/olaw/references/finalmou.htm) are:

  • Animal and Plant Health Inspection Service (APHIS), Animal Welfare, US Department of Agriculture: Has primary responsibility for overseeing compliance with the Animal Welfare Act and its implementing regulations (9 CFR Chapter 1, Subchapter A, Parts 1–3.) “The USDA regulations establish standards for the humane treatment of laboratory animals and a registration/ licensing procedure for identifying institutions that breed, sell, transport, hold, and use such animals. Compliance...is monitored by an active inspection program that provides for periodic inspections by veterinary medical officers or suitably trained paraprofessionals. Serious noncompliance is dealt with by procedures that range from civil penalties, to the issuance of "cease and desist" orders, to the confiscation of animals.”
  • NIH’s Office of Laboratory Animal Welfare (OLAW): Is responsible for the implementation of the Public Health Service Policy on Humane Care and Use of Laboratory Animals. The PHS policy “implements the Health Research Extension Act of 1985 (Public Law 99-158) and is based on the U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training.” Standards for institutional programs and facilities are described in the Guide for the Care and Use of Laboratory Animals. OLAW “fosters” compliance through the animal welfare assurance, which must be approved by OLAW and should describe the institution’s program in compliance with the PHS policy. OLAW “monitors compliance by evaluating institutional reports of noncompliance. Institutions are required to correct confirmed noncompliance and institute appropriate measures to prevent repeated noncompliance. Potential sanctions for continued noncompliance appear in the NIH Grants Policy Statement, Part II.”
  • Food and Drug Administration (FDA): Has primary responsibility for enforcing the Federal Food, Drug, and Cosmetic Act. The FFDCA’s good laboratory practice regulations (21 CFR Part 58) “establish standards for the proper conduct of nonclinical laboratory studies that include animals. Compliance is assessed through an active program of periodic inspections carried out by trained field inspectors. Serious noncompliance is dealt with by procedures ranging from study rejection to laboratory disqualification.”

Regulations


Policies and Principles


Resources for Investigators


Resources for IACUC Members


Departures from the Guide


Contact IACUC Program Staff

IACUC Program Manager/CLAF Manager Anthony “Tony” Munn AFLS A-42, (479) 575-2994, iacuc@uark.edu
IACUC Veterinarian John W. Hahn, DVM AFLS A-42, (479) 575-2994, jwhahn@uark.edu
IACUC Chair Craig Coon, Ph.D. POSC O-211, (479) 575-4134, ccoon@uark.edu
Director, Research Compliance Rosemary H. Ruff ADMN 206, (479) 575-2105, rruff@uark.edu


RESEARCH COMPLIANCE ALERT

The Central Lab Animal Facility has a new director, Tony Munn.  All questions concerning CLAF services and IACUC submissions should be directed to Tony, anthonym@uark.edu, 575-2994.  IACUC protocols and protocol modifications should be submitted by email to iacuc@uark.edu at least one week in advance of the next scheduled IACUC meeting. Please download and use the recently updated IACUC protocol forms